hrp0097p1-345 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

45 mg Subcutaneous Leuprolide Acetate Suppressed Unstimulated Luteinizing Hormone (LH) to Prepubertal Concentrations

Miller Bradley , Boldt-Houle Deborah , Daugherty Rhea , Atkinson Stuart

Background: There is evidence that unstimulated LH concentrations may be appropriate to monitor hormone suppression in children with central precocious puberty (CPP) during treatment with gonadotropin-releasing hormone agonists (GnRHa). Literature suggests that unstimulated LH concentrations <0.3 and >0.8 IU/L are prepubertal and clearly pubertal, respectively. We present secondary analyses of unstimulated LH suppression data from the pivotal trial of th...